RED CELLS, IRON, AND ERYTHROPOIESIS Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes
نویسندگان
چکیده
1Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; 2Department of Medical Biology, University of Melbourne, Melbourne, Australia; 3Schools of Chemistry and Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom; 4Division of Rheumatology, Washington University School of Medicine, St Louis, MO; and 5Department of Microbiology, University of Ghana Medical School, Accra, Ghana
منابع مشابه
RED CELLS, IRON, AND ERYTHROPOIESIS Chemical activation of a high-affinity glutamate transporter in human erythrocytes and its implications for malaria-parasite–induced glutamate uptake
Human erythrocytes have a low basal permeability to L-glutamate and are not known to have a functional glutamate transporter. Here, treatment of human erythrocytes with arsenite was shown to induce the uptake of L-glutamate and D-aspartate, but not that of D-glutamate or L-alanine. The majority of the arseniteinduced L-glutamate influx was via a highaffinity, Na -dependent system showing charac...
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Heme oxygenase-1 is critical for iron recycling during red blood cell turnover, whereas its impact on steady-state erythropoiesis and red blood cell lifespan is not known. We show here that in 8- to 14-week old mice, heme oxygenase-1 deficiency adversely affects steady-state erythropoiesis in the bone marrow. This is manifested by a decrease in Ter-119(+)-erythroid cells, abnormal adhesion mole...
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